Focusing on three representation of posthuman bodies as cloned bodies in Kazuo Ishiguro’s Never Let Me Go (2005), toxic bodies in Indra Sinha’s Animal’s People (2007), and cyborg bodies in Justina Robson’s Natural History (2004) from the theoretical perspectives of posthuman definition of what it means to be human, this study discusses the changing concept of the body. In this context, the integral and dynamic connection between a human body and the world is of special significance, which opens up new possibilities to reconfigure the human body that is no longer conceded separate from the nonhuman world but embodied in it. Each of the novels significantly displays the in-betweenness of humans by making them interact with chemical substances, machines, and other nonhuman entities, and shows how clear-cut distinctions between the human and the nonhuman bodies have collapsed.